What is the meaning of Irritation?

The act of irritating or annoying.

The state of being irritated.

A thing or person that annoys.

A state of inflammation or of painful reaction to cell or tissue damage.

A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action.

irritation (all senses)

Source: wiktionary.org